Understand our biology, improve how our bodies function, and sustain
our ability to live, perform and thrive.
Genomic guided sustainable functional health.
Understanding of disease progression and suppression from foundational biology syntheses. Provide true guidelines for true recovery from chronic diseases.
National University of Singapore
Centre for MedTech & Innovations
PT Ganesha Matra Jaya
Singapore Health Technologies Consortium
co11ab Novena
Indonesia Neuroscience Institute
Eversana Life Sciences Services
Department of Health, Indonesia
A*StartCentral
Gene-lifestyle interaction interventions targeting the Renin-Angiotensin-Aldosterone System, autonomic vascular resistance, and sodium-potassium balance to regulate arterial pressure and preserve vascular elasticity.
Personalized carbohydrate tolerance profiling, chrononutrition guidance, and visceral adiposity reduction to alleviate pancreatic beta-cell strain, restore cellular insulin sensitivity, and achieve
durable remission.
Genomic lipid clearance modulation combining tailored dietary lipid substitution with sterol metabolism targeting to optimize hepatic LDLR uptake, lower circulating ApoB, and reverse atherogenic dyslipidemia.
A guided wellness journey powered by precision genomics and sustained through targeted lifestyle changes. We deliver digital therapeutic solutions designed to regulate blood pressure, remission of Type 2 diabetes, lipid optimization, and prevent heart disease and stroke.
Users undergo registration, pre-test consultation with consent, current health screening, family history collection, and pre-test genetic counselling.
Following blood or saliva sample collection, laboratory processing performs DNA genotyping or sequencing to generate PRS and gene-lifestyle interaction reports.
Integrating baseline biomarkers with genetic insights, clinicians formulate personalized lifestyle plans featuring tailored diet and exercise targets.
Annual risk-reduction targets are structured into actionable weekly goals, backed by dedicated nutrition and exercise coaching.
Continuous lifestyle tracking and periodic biomarker monitoring enable dynamic reviews of risk-reduction progress and chronic disease management.
Partner with Health BETA to deliver evidence-based, gene-lifestyle guided care
for cardiovascular and metabolic disease remission.
Health BETA’s algorithms and digital therapeutics are anchored in foundational discoveries from multi-ethnic Asian cohorts—uncovering causal variants, gene-lifestyle interactions (GxL), and validated prevention pathways.
Investigates functional polymorphisms in the PON1 gene (Q192R, L55M) and demonstrates significant synergistic gene-environment interaction with smoking, accelerating coronary atherogenesis through compromised antioxidant enzyme defenses.
Evaluates the additive discriminatory power of multi-locus genetic risk scores (GRS) over conventional clinical risk models in the Singapore Chinese population, establishing significant clinical risk reclassification for early cardiovascular prevention.
Validated across ~40,000 Chinese adults in prospective cohorts; proves that an ancestry-specific polygenic risk score reliably predicts lifetime CAD risk, and adherence to ideal cardiovascular health habits produces the largest absolute risk reduction in high-genetic-risk individuals.
Landmark study co-authored by Health BETA founding scientist a/Prof. Chew-Kiat Heng demonstrating how high-fiber psyllium dietary intervention downregulates hepatic lipogenesis genes (FASN) while upregulating bile acid synthesis and cholesterol clearance pathways (HMGCR, CYP7A1) to significantly lower circulating total cholesterol and triglycerides.
Large-scale meta-analysis of four genome-wide association studies across multi-ethnic Southeast Asian cohorts, uncovering an Asian-specific missense variant in APOA5 that significantly impacts circulating triglyceride levels and coronary artery disease susceptibility.
Global multi-ancestry meta-analysis revealing 4 genome-wide significant loci where habitual physical exercise directly modifies genetic control over HDL-C, LDL-C, and triglycerides—proving at the molecular level that exercise alters genomic cardiovascular predisposition.
Evaluated 97 BMI susceptibility loci across adult Singapore Chinese cohorts, identifying significant gene-diet interactions where macronutrient balance (carbohydrate quality and dietary fat) directly modulates genetic obesity risk.
Identifies novel East Asian genetic loci associated with exceptional healthy lifespan free from major chronic cardiometabolic diseases, offering molecular targets for genomic-guided longevity and preventative medicine.
CEO, Co-Founder
CSO, Co-Founder
Scientific Advisor
Business Development Director
Bussiness Dev. Director, Singapore
Research Collaborator
MBBS (S’pore), MMed (Int Med), MRCP (UK)
Advisor
MD, PhD, FACC, FAHA